Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.

Updated: 2017 Aug. 1

| Home | Kinexus | Contact | Credits

Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: TOP2B All Species: 25.76
Human Site: T1431 Identified Species: 40.48
UniProt: Q02880 Number Species: 14
    Phosphosite Substitution
    Charge Score: 0.07
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q02880 NP_001059.2 1626 183267 T1431 S P G K S K A T P E K S L H D
Chimpanzee Pan troglodytes XP_516332 1634 184611 T1439 S P G K S K A T P E K S L H D
Rhesus Macaque Macaca mulatta XP_001092092 1620 182490 T1425 S P G K S K A T P E K S L H D
Dog Lupus familis XP_534241 2041 231068 T1848 S P G K S K A T P E K S S H D
Cat Felis silvestris
Mouse Mus musculus Q64511 1612 181890 T1418 S S G K S K A T P E K S S N D
Rat Rattus norvegicus P41516 1526 173202 D1341 G L D E K D E D E D F F P L D
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001507216 1923 216719 T1731 S P V K S K P T P E K S S H D
Chicken Gallus gallus O42131 1627 183228 S1437 S P V K S K P S P E K M S Q E
Frog Xenopus laevis NP_001082502 1579 178601 A1393 A P K K A E K A K K T E S P E
Zebra Danio Brachydanio rerio NP_001038656 1618 182448 F1423 V D D D D D I F P P K T T F T
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P15348 1447 164377 E1262 K E P K K P K E P K E P K V K
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans Q23670 1520 172316 S1335 K T A K K E K S D G F N S D M
Sea Urchin Strong. purpuratus XP_783546 1448 163750 K1263 P R I D N L I K K A T G D G K
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana P30182 1473 164089 A1288 R Q G A K K K A P A A A K E V
Baker's Yeast Sacchar. cerevisiae P06786 1428 164196 T1243 V T K S K A P T K I K K E K T
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 98.3 98.5 78.1 N.A. 95.6 66.2 N.A. 79.3 89.2 66.6 73.6 N.A. 50.3 N.A. 49.5 57.3
Protein Similarity: 100 98.5 99.1 78.8 N.A. 97.2 78.1 N.A. 81.8 93.8 78.7 83.8 N.A. 64.3 N.A. 65.8 69.9
P-Site Identity: 100 100 100 93.3 N.A. 80 6.6 N.A. 80 53.3 13.3 13.3 N.A. 13.3 N.A. 6.6 0
P-Site Similarity: 100 100 100 93.3 N.A. 86.6 20 N.A. 80 66.6 46.6 20 N.A. 26.6 N.A. 26.6 6.6
Percent
Protein Identity: N.A. N.A. N.A. 43.3 40.7 N.A.
Protein Similarity: N.A. N.A. N.A. 59 56.8 N.A.
P-Site Identity: N.A. N.A. N.A. 20 13.3 N.A.
P-Site Similarity: N.A. N.A. N.A. 26.6 13.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 7 0 7 7 7 7 34 14 0 14 7 7 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 7 14 14 7 14 0 7 7 7 0 0 7 7 47 % D
% Glu: 0 7 0 7 0 14 7 7 7 47 7 7 7 7 14 % E
% Phe: 0 0 0 0 0 0 0 7 0 0 14 7 0 7 0 % F
% Gly: 7 0 40 0 0 0 0 0 0 7 0 7 0 7 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 34 0 % H
% Ile: 0 0 7 0 0 0 14 0 0 7 0 0 0 0 0 % I
% Lys: 14 0 14 67 34 54 27 7 20 14 60 7 14 7 14 % K
% Leu: 0 7 0 0 0 7 0 0 0 0 0 0 20 7 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 7 0 0 7 % M
% Asn: 0 0 0 0 7 0 0 0 0 0 0 7 0 7 0 % N
% Pro: 7 47 7 0 0 7 20 0 67 7 0 7 7 7 0 % P
% Gln: 0 7 0 0 0 0 0 0 0 0 0 0 0 7 0 % Q
% Arg: 7 7 0 0 0 0 0 0 0 0 0 0 0 0 0 % R
% Ser: 47 7 0 7 47 0 0 14 0 0 0 40 40 0 0 % S
% Thr: 0 14 0 0 0 0 0 47 0 0 14 7 7 0 14 % T
% Val: 14 0 14 0 0 0 0 0 0 0 0 0 0 7 7 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _